Model-based optimization of bacterial motility strategies for maximizing population yield

Engineering notes

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Chinese explanation / 中文解读

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Original abstract

Bacterial motility is a fundamental trait for territorial expansion and resource acquisition. While existing models of nutrient-dependent motility often do not explicitly account for the metabolic costs associated with motility, these costs become critical in nutrient-limited or closed systems. In this study, we developed a mathematical framework using partial differential equations (PDEs) that explicitly incorporates the energetic trade-offs of motility. By formulating an optimization problem focused on maximizing population yield---defined by the total cell count---we evaluated various motility strategies across different environmental contexts. Our results demonstrate that the optimal motility response is highly sensitive to resource distribution. Specifically, we show that in unpredictable environments, a non-monotonic motility response emerges as the optimal strategy, providing a robust theoretical explanation for dose-response curves observed in experimental microbiology. This framework serves as a powerful, interpretable tool for predicting bacterial behavior in resource-constrained ecosystems and offers new insights into how such adaptive strategies are shaped by environmental pressures.

Links and sources

• Official / arXiv page
• PDF from original source

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