Single-cell-level distributions and relationships can differentiate cell-division and growth models

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Original abstract

Complex interactions among regulatory molecules determine the rules underlying cell growth and division in microbial cells. While the governing molecular network may not always be obvious, it is well known that correlations among certain physiological quantities measured in experiments, such as birth-size, division-size, division-time, and division-added-size, can differentiate among various cell-division models, such as Timer, Sizer, and Adder. Here we show that, apart from these correlations, which we extend for the case of stochastic single-cell growth and stochastic asymmetric partitioning, probability distributions of these quantities and statistical relationships between them can also be used to differentiate between these division models. Interestingly, we show that these quantities can not only differentiate the division models, but also distinguish among the single-cell growth paradigms, such as linear and exponential growth. We then demonstrate this differentiability among various division and growth models by comparing our analytical results with published experimental data. We further show that these results remain valid even when the growth rate of a cell is correlated with the growth rate of cells from previous generations in the lineage.

Links and sources

• Official / arXiv page
• PDF from original source

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